WILLIAM CUMMING ROSE (April 4, 1887 – September 25, 1985) was an American biochemist and nutritionist . He discovered the amino acid threonine and his research determined the requirement for essential amino acids in diet.
* 1 Early life * 2 Career * 3 Awards and honors * 4 References * 5 External links
William Cumming Rose was born in Greenfield, South Carolina. His
father was a Presbyterian minister who began to homeschool William in
Latin, Greek, and Hebrew when he was 14 years old. He also studied an
introductory chemistry textbook by
Ira Remsen . When he was 16, he
Rose taught for a time at
University of Pennsylvania
At Illinois, Rose focused his research work on amino acid metabolism and nutrition. He found that the 19 amino acids then known were not sufficient for growth, and this led to his discovery in 1935 of the last of the common amino acids, α-amino-β-hydroxy-n-butyric acid, later named threonine. His studies also distinguished the amino acids that are absolutely essential from those that are necessary only for optimal growth. His studies further led him to the point where it was "practicable to evaluate proteins in terms of their ability to meet human needs." In June 1949 he published "Amino Acid Requirements of Man".
Rose served as President of the American Society of Biological Chemists from 1939 to 1941. He was appointed to the Food and Nutrition Board of the National Research Council, which advised government agencies on dietary recommendations. Rose retired from the University of Illinois in 1955.
He recalled the role of Yale through the work of Samuel William Johnson , Chittenden, and Mendel in 1977 with the article "Recollections of personalities involved in the early history of American biochemistry". Further, he recounted the biochemical advances he witnessed in "How did it happen".
AWARDS AND HONORS
* 1936 – Became a member of the
* ^ A B C Robert D. Simoni, Robert L. Hill and Martha Vaughan
(September 13, 2002). "The Discovery of the Amino Acid Threonine: the
Work of William C. Rose". Journal of Biological Chemistry. 277 (37):
56–58. PMID 12218068 .
* ^ A B McCoy, R. H., Meyer, C. E., and Rose, W. C. (1935).
"Feeding Experiments with Mixtures of Highly Purified Amino Acids.
VIII. Isolation and Identification of a New Essential Amino Acid"
(PDF). Journal of Biological Chemistry. 112: 283–302. CS1 maint:
Multiple names: authors list (link )
* ^ Thesis: Studies in intermediate metabolism; mucic acid and
carbohydrate metabolism; the physiology of cratine and cratinine
elimination, their relation to carbohydrate metabolism
* ^ The Department of
* H. E. Carter