A CATARACT is a clouding of the lens in the eye which leads to a decrease in vision . Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colors, blurry vision, halos around light, trouble with bright lights, and trouble seeing at night. This may result in trouble driving, reading, or recognizing faces. Poor vision caused by cataracts may also result in an increased risk of falling and depression . Cataracts are the cause of half of blindness and 33% of visual impairment worldwide.
Cataracts are most commonly due to aging but may also occur due to trauma or radiation exposure, be present from birth , or occur following eye surgery for other problems. Risk factors include diabetes , smoking tobacco , prolonged exposure to sunlight , and alcohol. Either clumps of protein or yellow-brown pigment may be deposited in the lens reducing the transmission of light to the retina at the back of the eye. Diagnosis is by an eye examination .
Prevention includes wearing sunglasses and not smoking. Early on the
symptoms may be improved with glasses . If this does not help, surgery
to remove the cloudy lens and replace it with an artificial lens is
the only effective treatment. Surgery is needed only if the cataracts
are causing problems and generally results in an improved quality of
About 20 million people are blind due to cataracts. It is the cause of approximately 5% of blindness in the United States and nearly 60% of blindness in parts of Africa and South America. Blindness from cataracts occurs in about 10 to 40 per 100,000 children in the developing world , and 1 to 4 per 100,000 children in the developed world . Cataracts become more common with age. More than half the people in the United States had cataracts by the age of 80.
* 1 Signs and symptoms
* 2 Causes
* 2.1 Age * 2.2 Trauma * 2.3 Radiation * 2.4 Genetics * 2.5 Skin diseases * 2.6 Smoking and alcohol * 2.7 Inadequate vitamin C * 2.8 Medications * 2.9 Post-operative * 2.10 Other diseases
* 3 Classification * 4 Prevention
* 5 Treatment
* 5.1 Surgical
* 6 Prognosis
* 6.1 Postoperative care * 6.2 Complications
* 7 Epidemiology
* 8 History
* 8.1 Etymology
* 9 Research * 10 See also * 11 References * 12 External links
SIGNS AND SYMPTOMS
An example of normal vision on the left versus vision with cataracts on the right Bilateral cataracts in an infant due to congenital rubella syndrome
Signs and symptoms vary depending on the type of cataract, though considerable overlap occurs. People with nuclear sclerotic or brunescent cataracts often notice a reduction of vision . Those with posterior subcapsular cataracts usually complain of glare as their major symptom.
The severity of cataract formation, assuming no other eye disease is present, is judged primarily by a visual acuity test. The appropriateness of surgery depends on a patient's particular functional and visual needs and other risk factors, all of which may vary widely.
Age is the most common cause. Lens proteins denature and degrade over time, and this process is accelerated by diseases such as diabetes mellitus and hypertension . Environmental factors, including toxins, radiation, and ultraviolet light , have cumulative effects, which are worsened by the loss of protective and restorative mechanisms due to alterations in gene expression and chemical processes within the eye.
Post traumatic rosette cataract of a 60 years old male
Blunt trauma causes swelling, thickening, and whitening of the lens fibers. While the swelling normally resolves with time, the white color may remain. In severe blunt trauma, or in injuries that penetrate the eye, the capsule in which the lens sits can be damaged. This damage allows fluid from other parts of the eye to rapidly enter the lens leading to swelling and then whitening, obstructing light from reaching the retina at the back of the eye. Cataracts may develop in 0.7 to 8.0% of cases following electrical injuries . Blunt trauma can also result in star- or petal-shaped cataracts.
Cataracts have been associated with ionizing radiation such as X-rays. The addition of damage to the DNA of the lens cells has been considered. Finally, electric and heat injuries denature and whiten the lens as a result of direct protein coagulation. This same process makes the clear albumen of an egg become white and opaque during cooking. Cataracts of this type are often seen in glassblowers and furnace workers. Lasers of sufficient power output are known to damage the eyes and skin.
Christmas tree cataract (Diffuse illumination)
The genetic component is strong in the development of cataracts,
most commonly through mechanisms that protect and maintain the lens.
The presence of cataracts in childhood or early life can occasionally
be due to a particular syndrome. Examples of chromosome abnormalities
associated with cataracts include
1q21.1 deletion syndrome ,
cri-du-chat syndrome ,
The skin and the lens have the same embryological origin and so can be affected by similar diseases. Those with atopic dermatitis and eczema occasionally develop shield ulcers cataracts. Ichthyosis is an autosomal recessive disorder associated with cuneiform cataracts and nuclear sclerosis. Basal-cell nevus and pemphigus have similar associations.
SMOKING AND ALCOHOL
Cigarette smoking has been shown to double the rate of nuclear sclerotic cataracts and triple the rate of posterior subcapsular cataracts. Evidence is conflicting over the effect of alcohol. Some surveys have shown a link, but others which followed people over longer terms have not.
INADEQUATE VITAMIN C
Low vitamin C intake and serum levels have been associated with greater cataract rates. However, use of supplements of vitamin C has not demonstrated benefit.
Some medications, such as systemic, topical, or inhaled corticosteroids , may increase the risk of cataract development. Corticosteroids most commonly cause posterior subcapsular cataracts. People with schizophrenia often have risk factors for lens opacities (such as diabetes, hypertension, and poor nutrition) but antipsychotic medications are unlikely to contribute to cataract formation. Miotics and triparanol may increase the risk.
Nearly every person who undergoes a vitrectomy —without ever having had cataract surgery—will experience progression of nuclear sclerosis after the operation. This may be because the native vitreous humor is different to the solutions used to replace the vitreous (vitreous substitutes ), such as BSS Plus . This may also be because the native vitreous humour contains ascorbic acid which helps neutralize oxidative damage to the lens and because traditional vitreous substitutes do not contain ascorbic acid. As such, for phakic patients requiring a vitrectomy it is becoming increasingly common for ophthalmologists to offer the vitrectomy with a combined prophylactic cataract surgery procedure to prophylactically prevent cataract formation.
* Metabolic and nutritional diseases
Aminoaciduria or Lowe\'s syndrome
* Genetic syndromes
* Secondary to other eye diseases:
Sunflower cataract of a 40 years old male with Wilson's disease and decompensated CLD A cat with cataracts in both eyes.
Cross-sectional view, showing the position of the human lens
Cataracts may be partial or complete, stationary or progressive, or hard or soft. The main types of age-related cataracts are nuclear sclerosis, cortical, and posterior subcapsular.
Cortical cataracts are due to the lens cortex (outer layer) becoming opaque. They occur when changes in the fluid contained in the periphery of the lens causes fissuring. When these cataracts are viewed through an ophthalmoscope , or other magnification system, the appearance is similar to white spokes of a wheel. Symptoms often include problems with glare and light scatter at night.
Posterior subcapsular cataracts are cloudy at the back of the lens adjacent to the capsule (or bag) in which the lens sits. Because light becomes more focused toward the back of the lens, they can cause disproportionate symptoms for their size.
An immature cataract has some transparent protein, but with a mature cataract, all the lens protein is opaque. In a hypermature or Morgagnian cataract, the lens proteins have become liquid. Congenital cataract, which may be detected in adulthood, has a different classification and includes lamellar, polar, and sutural cataracts.
Cataracts can be classified by using the lens opacities classification system LOCS III. In this system, cataracts are classified based on type as nuclear, cortical, or posterior. The cataracts are further classified based on severity on a scale from 1 to 5. The LOCS III system is highly reproducible.
DIFFERENT TYPES OF CATARACTS
Posterior polar cataract of an 8 year old boy in left eye
Cortical cataract of a 60 year old male
Retroillumination of cortical cataract
Posterior subcapsular cataract of a 16 year old girl with IDDM
Intumescent cataract of a 55 year old male
Anterior subcapsular cataract having back shadow
Posterior subcapsular cataract by retroillumination
Dense white mature cataract of a 60 year old male
Risk factors such as UVB exposure and smoking can be addressed. Although no means of preventing cataracts has been scientifically proven, wearing sunglasses that counteract ultraviolet light may slow their development. While adequate intake of antioxidants (such as vitamins A, C, and E) has been thought to protect against the risk of cataracts, clinical trials have shown no benefit from supplements; though evidence is mixed, but weakly positive, for a potential protective effect of the nutrients lutein and zeaxanthin . Statin use is somewhat associated with a lower risk of nuclear sclerotic cataracts.
Several recent evaluations found that cataract surgery can meet expectations only when significant functional impairment due to cataracts exists before surgery. Visual function estimates such as VF-14 have been found to give more realistic estimates than visual acuity testing alone. In some developed countries, a trend to overuse cataract surgery has been noted, which may lead to disappointing results.
Phacoemulsification is the most widely used cataract surgery in the developed world. This procedure uses ultrasonic energy to emulsify the cataract lens. Phacoemulsification typically comprises six steps:
* Anaesthetic – The eye is numbed with either a subtenon injection around the eye (see: retrobulbar block ) or topical anesthetic eye drops. The former also provides paralysis of the eye muscles. * Corneal incision – Two cuts are made at the margin of the clear cornea to allow insertion of instruments into the eye. * Capsulorhexis – A needle or small pair of forceps is used to create a circular hole in the capsule in which the lens sits. * Phacoemulsification – A handheld ultrasonic probe is used to break up and emulsify the lens into liquid using the energy of ultrasound waves. The resulting 'emulsion' is sucked away. * Irrigation and aspiration – The cortex, which is the soft outer layer of the cataract, is aspirated or sucked away. Fluid removed is continually replaced with a saline solution to prevent collapse of the structure of the anterior chamber (the front part of the eye). * Lens insertion – A plastic, foldable lens is inserted into the capsular bag that formerly contained the natural lens. Some surgeons also inject an antibiotic into the eye to reduce the risk of infection. The final step is to inject salt water into the corneal wounds to cause the area to swell and seal the incision.
Extracapsular cataract extraction (ECCE) consists of removing the lens manually, but leaving the majority of the capsule intact. The lens is expressed through a 10- to 12-mm incision which is closed with sutures at the end of surgery. ECCE is less frequently performed than phacoemulsification, but can be useful when dealing with very hard cataracts or other situations where emulsification is problematic. Manual small incision cataract surgery (MSICS) has evolved from ECCE. In MSICS, the lens is removed through a self-sealing scleral tunnel wound in the sclera which, ideally, is watertight and does not require suturing. Although "small", the incision is still markedly larger than the portal in phacoemulsion. This surgery is increasingly popular in the developing world where access to phacoemulsification is still limited.
Intracapsular cataract extraction (ICCE) is rarely performed. The lens and surrounding capsule are removed in one piece through a large incision while pressure is applied to the vitreous membrane. The surgery has a high rate of complications.
The postoperative recovery period (after removing the cataract) is usually short. The patient is usually ambulatory on the day of surgery, but is advised to move cautiously and avoid straining or heavy lifting for about a month. The eye is usually patched on the day of surgery and use of an eye shield at night is often suggested for several days after surgery.
In all types of surgery, the cataractous lens is removed and replaced with an artificial lens, known as an intraocular lens , which stays in the eye permanently. Intraocular lenses are usually monofocal, correcting for either distance or near vision. Multifocal lenses may be implanted to improve near and distance vision simultaneously, but these lenses may increase the chance of unsatisfactory vision.
Serious complications of cataract surgery include retinal detachment and endophthalmitis . In both cases, patients notice a sudden decrease in vision. In endophthalmitis, patients often describe pain. Retinal detachment frequently presents with unilateral visual field defects, blurring of vision, flashes of light, or floating spots.
The risk of retinal detachment was estimated as about 0.4% within 5.5 years, corresponding to a 2.3-fold risk increase compared to naturally expected incidence, with older studies reporting a substantially higher risk. The incidence is increasing over time in a somewhat linear manner, and the risk increase lasts for at least 20 years after the procedure. Particular risk factors are younger age, male sex, longer axial length, and complications during surgery. In the highest risk group of patients, the incidence of pseudophakic retinal detachment may be as high as 20%.
The risk of endophthalmitis occurring after surgery is less than one in 1000.
Corneal edema and cystoid macular edema are less serious but more common, and occur because of persistent swelling at the front of the eye in corneal edema or back of the eye in cystoid macular edema. They are normally the result of excessive inflammation following surgery, and in both cases, patients may notice blurred, foggy vision. They normally improve with time and with application of anti-inflammatory drops. The risk of either occurring is around one in 100. It is unclear whether NSAIDs or corticosteroids are superior at reducing postoperative inflammation.
Posterior capsular opacification, also known as after-cataract, is a condition in which months or years after successful cataract surgery, vision deteriorates or problems with glare and light scattering recur, usually due to thickening of the back or posterior capsule surrounding the implanted lens, so-called 'posterior lens capsule opacification'. Growth of natural lens cells remaining after the natural lens was removed may be the cause, and the younger the patient, the greater the chance of this occurring. Management involves cutting a small, circular area in the posterior capsule with targeted beams of energy from a laser, called Nd:YAG laser capsulotomy, after the type of laser used. The laser can be aimed very accurately, and the small part of the capsule which is cut falls harmlessly to the bottom of the inside of the eye. This procedure leaves sufficient capsule to hold the lens in place, but removes enough to allow light to pass directly through to the retina. Serious side effects are rare. Posterior capsular opacification is common and occurs following up to one in four operations, but these rates are decreasing following the introduction of modern intraocular lenses together with a better understanding of the causes.
Vitreous touch syndrome is a possible complication of intracapsular cataract extraction.
Disability-adjusted life years for cataracts per 100,000 inhabitants in 2004:
no data 990
Age-related cataracts are responsible for 51% of world blindness, about 20 million people. Globally, cataracts cause moderate to severe disability in 53.8 million (2004), 52.2 million of whom are in low and middle income countries.
In many countries, surgical services are inadequate, and cataracts remain the leading cause of blindness. Even where surgical services are available, low vision associated with cataracts may still be prevalent as a result of long waits for, and barriers to, surgery, such as cost, lack of information and transportation problems.
In the United States, age-related lens changes have been reported in 42% between the ages of 52 and 64, 60% between the ages 65 and 74, and 91% between the ages of 75 and 85. Cataracts affect nearly 22 million Americans age 40 and older. By age 80, more than half of all Americans have cataracts. Direct medical costs for cataract treatment are estimated at $6.8 billion annually.
In the eastern Mediterranean region, cataracts are responsible for over 51% of blindness. Access to eye care in many countries in this region is limited. Childhood-related cataracts are responsible for 5–20% of world childhood blindness.
The first references to cataracts and their treatment in Ancient Rome are found in 29 AD in De Medicinae, the work of the Latin encyclopedist Aulus Cornelius Celsus . Archaeological evidence of eye surgery in the Roman era also exists.
Muslim ophthalmologist Ammar ibn Ali, in his Choice of
"Cataract" is derived from the
Femtosecond laser mode-locking , used during cataract surgery, was originally used to cut accurate and predictable flaps in LASIK surgery, and has been introduced to cataract surgery. The incision at the junction of the sclera and cornea and the hole in capsule during capsulorhexis, traditionally made with a handheld blade, needle, and forceps, are dependent on skill and experience of the surgeon. Sophisticated three-dimensional images of the eyes can be used to guide lasers to make these incisions. Nd:YAG laser can also then break up the cataract as in phacoemulsification.
Stem cells have been used in a clinical trial for lens regeneration in twelve children under the age of two with cataracts present at birth. The children were followed for six months, so it is unknown what the long-term results will be, and it is unknown if this procedure would work in adults.
* ^ A B C D E F G H I J K L M "Facts About Cataract". September
2009. Retrieved 24 May 2015.
* ^ A B Gimbel, HV; Dardzhikova, AA (January 2011). "Consequences
of waiting for cataract surgery.". Current Opinion in Ophthalmology.
22 (1): 28–30. PMID 21076306 . doi :10.1097/icu.0b013e328341425d .
* ^ A B "
* ^ "cataract". Word of the Day. Dictionary.com. 29 October 2003.
"cataract". Oxford Dictionaries. Oxford University Press. * ^
cataracta, Charlton T. Lewis, Charles Short, A
* ^ Toh T, Morton J, Coxon J, Elder MJ (2007). "Medical treatment
of cataract". Clin. Experiment. Ophthalmol. 35 (7): 664–71. PMID
17894689 . doi :10.1111/j.1442-9071.2007.01559.x .
* ^ Friedman NJ, Palanker DV, Schuele G, Andersen D, Marcellino G,
Seibel BS, Batlle J, Feliz R, Talamo JH, Blumenkranz MS, Culbertson WW
(July 2011). "Femtosecond laser capsulotomy". J.
* ICD -10 : H25-H26, H28, Q12.0 * ICD -9-CM : 366 * DISEASESDB : 2179
* MEDLINEPLUS : 001001