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AryoGen
ARYOGEN PHARMED (in Persian: آریوژن فارمد ) is an Iranian biopharmaceutical company specializing in manufacturing Therapeutic Monoclonal antibodies
Monoclonal antibodies
and some other recombinant proteins . CONTENTS * 1 History * 2 Products * 3 See also * 4 References * 5 External links HISTORY AryoGen
AryoGen
is a biopharmaceutical company created on the mandate of Iranian executive branch. It was created a group of scientific experts spun off a well versed Biopharmaceutical
Biopharmaceutical
company, which formed a totally new entity christened as AryoGen
AryoGen
Biopharma which started its production in 2011. It was deemed an issue of national interest due to the importance of the target products on Iran's community health care system, as well as its impact in the region and around the world
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Etanercept
ETANERCEPT (trade name ENBREL) is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF; a soluble inflammatory cytokine) by acting as a TNF inhibitor . It has U.S. F.D.A. approval to treat rheumatoid arthritis , juvenile rheumatoid arthritis and psoriatic arthritis , plaque psoriasis and ankylosing spondylitis . TNF-alpha
TNF-alpha
is the "master regulator" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha. Etanercept is a fusion protein produced by recombinant DNA . It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2 , which is a receptor that binds to tumor necrosis factor-alpha
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Coagulation
COAGULATION (also known as CLOTTING) is the process by which blood changes from a liquid to a gel, forming a blood clot . It potentially results in hemostasis , the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along with deposition and maturation of fibrin . Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising ) or obstructive clotting (thrombosis ). Coagulation is highly conserved throughout biology; in all mammals , coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the most extensively researched and is the best understood. Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel
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List Of Business Entities
A BUSINESS ENTITY is an entity that is formed and administered as per corporate law in order to engage in business activities, charitable work, or other activities allowable. Most often, business entities are formed to sell a product or a service. There are many types of business entities defined in the legal systems of various countries. These include corporations , cooperatives , partnerships , sole traders , limited liability company and other specifically permitted and labelled types of entities. The specific rules vary by country and by state or province. Some of these types are listed below, by country
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Trastuzumab
TRASTUZUMAB, sold under the brand name HERCEPTIN among others, is a monoclonal antibody used to treat breast cancer . Specifically it is used for breast cancer that is HER2 receptor positive . It may be used by itself or together with other chemotherapy medication . Trastuzumab
Trastuzumab
is given by slow injection into a vein and injection just under the skin . Common side effects include fever, infection, cough, headache, trouble sleeping, and rash. Other severe side effects include heart failure , allergic reactions , and lung disease . Use during pregnancy may harm the baby. Trastuzumab
Trastuzumab
works by binding to the HER2 receptor and slowing down cell duplication. Trastuzumab
Trastuzumab
was approved for medical use in the United States in 1998
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Bevacizumab
BEVACIZUMAB, sold under the trade name AVASTIN, is medication used to treat a number of types of cancers and a specific eye disease . For cancer it is given by slow injection into a vein and used for colon cancer , lung cancer , glioblastoma , and renal-cell carcinoma . For age-related macular degeneration it is given by injection into the eye. Common side effects when use for cancer include nose bleeds , headache, high blood pressure, and rash. Other severe side effects include gastrointestinal perforation , bleeding, allergic reactions , blood clots , and an increased risk of infection. When used for eye disease side effects can include vision loss and retinal detachment . Bevacizumab
Bevacizumab
is in the angiogenesis inhibitor and monoclonal antibody families of medication. It works by slowing the growth of new blood vessels . Bevacizumab
Bevacizumab
was approved for medical use in the United States in 2004
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Special
SPECIAL or SPECIALS may refer to: CONTENTS * 1 Music * 2 Film and television * 3 Other uses * 4 See also MUSIC * Special (album) , a 1992 album by Vesta Williams * "Special" (Garbage song) , 1998 * "Special" (Mew song) , 2005 * "Special" (Stephen Lynch song) , 2000 * The Specials
The Specials
, a British band * "Special", a song by Violent Femmes on The Blind Leading the Naked * "Special", a song on
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MENA Report
MENA REPORT (MIDDLE EAST AND NORTH AFRICA BUSINESS REPORT) is a business news source established in 2001 and run by Al Bawaba ( Amman
Amman
, Jordan, and Dubai
Dubai
). It covers business and economics across the Arabic world
Arabic world
. PROFILEThe Mena Report was established in 2001. It covers economy and trade, IT and telecom, financial markets, oil and energy, agriculture, general industry, retail and services, transport and tourism. At time of launch, Menafn.com and Zawya.com provided similar content as the Mena Report. Al Bawaba employs journalists and editors to cover news and events in the Middle East and North Africa. The content is presented on Al Bawaba's own website, and is syndicated to other publishers and aggregators. In 2009 the Mena Report portal claimed to have 123,409 monthly site visits. REFERENCES * ^ A B "Al Bawaba"
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Monoclonal Antibodies
MONOCLONAL ANTIBODIES (MAB or MOAB) are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, in that they bind to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different plasma cell (antibody secreting immune cell) lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one single monoclonal antibody to two epitopes. Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry , molecular biology , and medicine
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Recombinant Proteins
RECOMBINANT DNA (RDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning ) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome . Recombinant DNA is possible because DNA molecules from all organisms share the same chemical structure. They differ only in the nucleotide sequence within that identical overall structure. Recombinant DNA is the general name for a piece of DNA that has been created by the combination of at least two strands. Recombinant DNA molecules are sometimes called CHIMERIC DNA, because they can be made of material from two different species, like the mythical chimera . R-DNA technology uses palindromic sequences and leads to the production of sticky and blunt ends . The DNA sequences used in the construction of recombinant DNA molecules can originate from any species
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1000000 (number)
1,000,000 (ONE MILLION), or one thousand thousand, is the natural number following 999,999 and preceding 1,000,001. The word is derived from the early Italian millione (milione in modern Italian), from mille, "thousand ", plus the augmentative suffix -one. It is commonly abbreviated as M (not to be confused with the metric prefix for 6997100000000000000♠1×10−3) or M; further MM ("thousand thousands", from Latin "Mille"; not to be confused with the Roman numeral MM = 2,000), MM, or MN in financial contexts. In scientific notation , it is written as 7006100000000000000♠1×106 or 106. Physical quantities can also be expressed using the SI prefix
SI prefix
mega (M), when dealing with SI units; for example, 1 megawatt (1 MW) equals 1,000,000 watts . The meaning of the word "million" is common to the short scale and long scale numbering systems, unlike the larger numbers, which have different names in the two systems
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Private Company
A PRIVATELY HELD COMPANY or CLOSE CORPORATION is a business company owned either by non-governmental organizations or by a relatively small number of shareholders or company members which does not offer or trade its company stock (shares ) to the general public on the stock market exchanges, but rather the company's stock is offered, owned and traded or exchanged privately. More ambiguous terms for a privately held company are UNQUOTED COMPANY and UNLISTED COMPANY. Though less visible than their publicly traded counterparts, private companies have major importance in the world's economy . In 2008, the 441 largest private companies in the United States accounted for US$ 1,800,000,000,000 in revenues and employed 6.2 million people, according to Forbes
Forbes
. In 2005, using a substantially smaller pool size (22.7%) for comparison, the 339 companies on Forbes
Forbes
' survey of closely held U.S
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Chairman
The CHAIRMAN (also CHAIRPERSON, CHAIRWOMAN or CHAIR) is the highest officer of an organized group such as a board , a committee , or a deliberative assembly . The person holding the office is typically elected or appointed by the members of the group. The chairman presides over meetings of the assembled group and conducts its business in an orderly fashion. When the group is not in session, the officer's duties often include acting as its head, its representative to the outside world and its spokesperson. In some organizations, this position is also called president (or other title), in others, where a board appoints a president (or other title), the two different terms are used for distinctly different positions
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Pharmaceutical Industry
The PHARMACEUTICAL INDUSTRY discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications . Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting , testing, safety, efficacy and marketing of drugs
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Monoclonal Antibody
MONOCLONAL ANTIBODIES (MAB or MOAB) are antibodies that are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, in that they bind to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different plasma cell (antibody secreting immune cell) lineages. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one single monoclonal antibody to two epitopes. Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry , molecular biology , and medicine
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Biopharmaceutical
A BIOPHARMACEUTICAL, also known as a BIOLOGIC(AL) MEDICAL PRODUCT, BIOLOGICAL, or BIOLOGIC, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines , blood , blood components, allergenics , somatic cells , gene therapies , tissues , recombinant therapeutic protein , and living cells used in cell therapy . Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources—human, animal, plant, fungal, or microbial. Terminology surrounding biopharmaceuticals varies between groups and entities, with different terms referring to different subsets of therapeutics within the general biopharmaceutical category
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